Description

5-Vinyl-2'-Deoxycytidine is a chemically modified nucleoside analog, a critical building block in advanced pharmaceutical and life science research. This compound is essential for the synthesis of oligonucleotides, particularly for applications in antisense therapy, siRNA, and diagnostic probe development. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on next-generation therapeutic modalities.

Application

• Oligonucleotide Synthesis: A key monomer for the solid-phase synthesis of modified DNA strands, enabling the creation of stable and targeted antisense oligonucleotides.
• Antisense Therapy Research: Used in the development of therapeutic agents designed to bind to specific RNA sequences to modulate gene expression for treating genetic disorders and cancers.
• siRNA and miRNA Tools: Incorporated into small interfering RNA (siRNA) or microRNA (miRNA) constructs to enhance stability and specificity in gene silencing applications.
• Diagnostic Probe Development: Serves as a modified base in fluorescent probes and molecular beacons for highly sensitive detection of nucleic acid sequences in diagnostic assays.
• Medicinal Chemistry & Drug Discovery: Employed as a versatile intermediate in the design and synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Bioconjugation and Labeling: The vinyl group provides a reactive handle for further chemical modifications, such as click chemistry, for attaching fluorophores or other functional groups.

Basic Information

Product Name	5-Vinyl-2'-Deoxycytidine
CAS No.	84574-81-2
Molecular Formula	C11H15N3O4
Molecular Weight	253.25 g/mol
Synonyms	5-Vinyl-deoxycytidine; 2'-Deoxy-5-vinylcytidine; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-5-vinylpyrimidine-2,4(1H,3H)-dione; 5-Ethenyl-2'-deoxycytidine; dC(V); Vinyl-dC; 5-Vinylcytidine deoxy
EINECS	Contact for details

Quality Control

Our 5-Vinyl-2'-Deoxycytidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and LC-MS for identity verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.