Description

5-Propynyl-2'-Deoxyuridine is a modified nucleoside analog, a key building block in the synthesis of oligonucleotides and probes for molecular biology and diagnostic applications. Its unique propynyl modification enhances binding affinity and stability, making it a critical reagent for advanced research and development. This compound is essential for pharmaceutical R&D, academic research, and diagnostic kit manufacturers focused on nucleic acid chemistry and probe design.

Application

• Oligonucleotide Synthesis: A crucial phosphoramidite precursor for incorporating modified bases into DNA and RNA strands to enhance hybridization properties.
• Molecular Probe Development: Used in the creation of high-affinity probes for fluorescence in situ hybridization (FISH), PCR, and other diagnostic assays.
• Antiviral & Anticancer Research: Serves as a scaffold for developing novel nucleoside analog therapeutics targeting viral polymerases and cellular DNA replication.
• Bioconjugation & Labeling: The alkyne group enables click chemistry for attaching fluorescent dyes, biotin, or other reporter molecules to nucleic acids.
• Structural Biology Studies: Utilized to investigate DNA-protein interactions and the structural impact of modified nucleotides.
• Diagnostic Kit Manufacturing: A key raw material for producing specialized reagents used in clinical and research diagnostic platforms.

Basic Information

Product Name	5-Propynyl-2'-Deoxyuridine
CAS No.	84558-94-1
Molecular Formula	C12H14N2O5
Molecular Weight	266.25 g/mol
Synonyms	5-Propynyl-dU; 5-(2-Propynyl)-2'-deoxyuridine; 2'-Deoxy-5-propynyluridine; 5-Prop-1-ynyl-2'-deoxyuridine; 5-(Prop-2-yn-1-yl)-2'-deoxyuridine; dU(Prop); 5-Propyne-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Our 5-Propynyl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and moisture. Certificates of Analysis (COA) with detailed specifications are provided to ensure compliance with research and pharmaceutical intermediate standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.