Description

1-Methyl-1H-Pyrazole-3-Carbonyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 1-methylpyrazole-3-carbonyl moiety, a key structural feature in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for constructing complex heterocyclic molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the production of modern pesticides and herbicides, where the pyrazole core contributes to biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functional polymers and organic electronic materials with specific optoelectronic properties.
• Peptide Mimetics & Bioconjugation: Facilitates the acylation of amines in peptides or biomolecules to create stable amide bonds for probe or conjugate development.
• Custom Synthesis & Contract Manufacturing: A high-value intermediate for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	1-Methyl-1H-Pyrazole-3-Carbonyl Chloride
CAS No.	84547-60-4
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	1-Methyl-1H-pyrazole-3-carbonyl chloride; 1-Methylpyrazole-3-carbonyl chloride; 3-Carbonyl chloride-1-methylpyrazole; 1-Methyl-1H-pyrazole-3-carboxylic acid chloride; 1-Methylpyrazole-3-carboxylic acid chloride; 1-Methyl-3-pyrazolecarbonyl chloride; 84547-60-4
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Pyrazole-3-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by IR and NMR spectroscopy, to ensure it meets the high standards required for synthetic applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, alcohols, and moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.