Description

1-Methyl-1H-Pyrazole-5-Carbonyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 1-methylpyrazole-5-carbonyl moiety, a key structural feature in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to create novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and other small-molecule drug discovery programs.
• Agrochemical Synthesis: Used in the production of modern pesticides, herbicides, and fungicides where the pyrazole ring system confers specific biological activity.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for metal-organic frameworks (MOFs) and catalysts for asymmetric synthesis.
• Material Science Precursor: Acts as a monomer or functionalization agent in the synthesis of polymers and advanced functional materials.
• Peptide Mimetics and Bioconjugation: Useful for modifying peptides or creating peptide-like structures (peptidomimetics) and for bioconjugation chemistry.
• Custom Synthesis and R&D: A vital reagent for contract research organizations (CROs) and academic laboratories engaged in novel heterocyclic chemistry.

Basic Information

Product Name	1-Methyl-1H-Pyrazole-5-Carbonyl Chloride
CAS No.	84547-59-1
Molecular Formula	C5H5ClN2O
Molecular Weight	144.56 g/mol
Synonyms	1-Methyl-1H-pyrazole-5-carbonyl chloride; 1-Methylpyrazole-5-carbonyl chloride; 5-(Chlorocarbonyl)-1-methyl-1H-pyrazole; 1-Methyl-5-pyrazolecarbonyl chloride; 1-Methyl-1H-pyrazole-5-carboxylic acid chloride; 1-Methylpyrazole-5-carboxylic acid chloride; 1-Methyl-5-carboxypyrazole chloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-1H-Pyrazole-5-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency suitable for demanding synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.