Description

1-tert-Butyl 2-Methyl 4-Azidopyrrolidine-1,2-Dicarboxylate is a high-purity, protected azido-pyrrolidine derivative, a crucial building block in advanced organic synthesis. Its value lies in its bifunctional nature, offering both a reactive azide group for click chemistry and protected carboxylates for selective deprotection and further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, especially those utilizing azide-alkyne cycloaddition (Click Chemistry) for bioconjugation or library synthesis.
• Peptidomimetic Research: Serves as a constrained proline analog for constructing novel peptide-like structures with enhanced metabolic stability and bioavailability.
• Agrochemical Development: Used in the research and production of advanced crop protection agents and herbicides.
• Material Science: Acts as a monomer or cross-linking agent in the development of specialized polymers and functional materials.
• Chemical Biology Probes: Enables the labeling and study of biological systems through its reactive azide functionality.
• Academic & R&D: A valuable reagent for methodological development in synthetic organic chemistry and medicinal chemistry programs.

Basic Information

Product Name	1-tert-Butyl 2-Methyl 4-Azidopyrrolidine-1,2-Dicarboxylate
CAS No.	84520-68-3
Molecular Formula	C12H20N4O4
Molecular Weight	284.31 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-(methoxycarbonyl)-4-azidopyrrolidine; 4-Azido-1-Boc-2-COOMe-pyrrolidine; 1-Boc-2-methyl 4-azidopyrrolidine-1,2-dicarboxylate; 4-Azidopyrrolidine-1,2-dicarboxylic acid 1-tert-butyl 2-methyl ester; tert-Butyl methyl 4-azidopyrrolidine-1,2-dicarboxylate; Boc-AzPro-OMe; (2S,4S)-1-tert-Butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate (for stereoisomer); (2R,4R)-1-tert-Butyl 2-methyl 4-azidopyrrolidine-1,2-dicarboxylate (for stereoisomer)
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 2-Methyl 4-Azidopyrrolidine-1,2-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment ensures the material meets the high standards required for research and cGMP intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, storage at 2-8°C is recommended. Keep away from heat, sparks, and open flames. Due to the presence of an azide group, avoid contact with heavy metals and strong reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.