Description

2',3',5'-Tri-o-Acetyl-5-(Trifluoromethyl) Uridine is a key protected nucleoside derivative, specifically a trifluoromethylated and acetylated uridine analog. This compound is of significant value as a critical synthetic intermediate in the development of novel pharmaceuticals and bioactive molecules, particularly in antiviral and anticancer research. It is primarily needed by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in nucleoside chemistry and prodrug synthesis. The acetyl protecting groups offer strategic advantages for selective deprotection and further functionalization in complex synthetic pathways.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of modified nucleoside analogs for potential antiviral and anticancer agents.
• Antiviral Drug Research: Used in the development and study of novel compounds targeting viral polymerases and replication mechanisms.
• Prodrug Synthesis: The acetylated form is a common precursor for creating prodrugs with enhanced bioavailability and targeted delivery.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies to understand nucleic acid metabolism and related biological pathways.
• Medicinal Chemistry: A valuable scaffold for structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Labeled Compound Synthesis: Can be used as a starting material for introducing the trifluoromethyl group or isotopic labels for tracer studies.

Basic Information

Product Name	2',3',5'-Tri-o-Acetyl-5-(Trifluoromethyl) Uridine
CAS No.	84500-34-5
Molecular Formula	C₁₆H₁₇F₃N₂O₈
Molecular Weight	422.31 g/mol
Synonyms	5-(Trifluoromethyl)uridine 2',3',5'-triacetate; 1-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(acetoxymethyl)oxolan-2-yl]-5-(trifluoromethyl)pyrimidine-2,4-dione; 2',3',5'-Tri-O-acetyl-5-trifluoromethyluridine; 5-Trifluoromethyluridine-2',3',5'-triacetate; 5-CF3-Uridine triacetate; 5-Trifluoromethyl-2',3',5'-tri-O-acetyluridine
EINECS	Contact for details

Quality Control

Our 2',3',5'-Tri-o-Acetyl-5-(Trifluoromethyl) Uridine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.