Description

5-Iodo-2',3',5'-Tri-o-Acetyluridine is a key protected nucleoside derivative used as a versatile building block in synthetic organic chemistry. This compound is essential for the controlled synthesis of modified oligonucleotides and nucleoside analogs, enabling precise structural modifications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of antiviral agents, anticancer drugs, and molecular probes. Its acetyl-protected sugar moiety provides stability and selectivity for subsequent chemical transformations.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of novel nucleoside-based antiviral and anticancer therapeutics.
• Oligonucleotide Synthesis: Used in the preparation of iodinated or modified oligonucleotides for research and diagnostic applications.
• Bioconjugation & Probe Development: Serves as a precursor for creating labeled nucleosides used in biophysical studies and imaging.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by introducing iodine as a heavy atom or for further functionalization via cross-coupling reactions.
• Process Chemistry: Employed in scaling up the production of active pharmaceutical ingredients (APIs) that contain modified uridine scaffolds.

Basic Information

Product Name	5-Iodo-2',3',5'-Tri-o-Acetyluridine
CAS No.	84500-33-4
Molecular Formula	C15H17IN2O9
Molecular Weight	496.21 g/mol
Synonyms	5-Iodo-2',3',5'-tri-O-acetyluridine; 1-[(2R,3R,4R,5R)-3,4-Diacetoxy-5-(acetoxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione; 2',3',5'-Tri-O-acetyl-5-iodouridine; 5-Iodouridine 2',3',5'-triacetate; Uridine, 5-iodo-, 2',3',5'-triacetate
EINECS	Contact for details

Quality Control

Our 5-Iodo-2',3',5'-Tri-o-Acetyluridine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines for the production of pharmaceutical intermediates, and our quality system is designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.