Description

Uridine, 3'-Azido-2',3'-Dideoxy-5'-o-(Triphenylmethyl)- is a key nucleoside derivative and a crucial synthetic intermediate in organic and medicinal chemistry. This compound matters for its role as a protected building block in the synthesis of modified oligonucleotides and nucleoside analogs, enabling advanced research and development. It is primarily needed by pharmaceutical R&D teams, biotechnology companies, and academic laboratories focused on antiviral drug discovery, antisense oligonucleotide therapeutics, and chemical biology studies.

Application

• Antiviral Drug Discovery: A critical precursor in the synthesis of nucleoside reverse transcriptase inhibitors (NRTIs) and other antiviral agents.
• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase synthesis of modified DNA/RNA strands, particularly those requiring azido-functionalized backbones.
• Chemical Biology Probes: Used to create labeled nucleosides for "click chemistry" applications, enabling the study of nucleic acid metabolism and interactions.
• Medicinal Chemistry Research: A versatile intermediate for structure-activity relationship (SAR) studies to develop novel therapeutic candidates.
• Bioconjugation: The azido group allows for efficient conjugation with alkynes via copper-catalyzed azide-alkyne cycloaddition (CuAAC), useful for tagging and tracking.

Basic Information

Item	Detail
Product Name	Uridine, 3'-Azido-2',3'-Dideoxy-5'-o-(Triphenylmethyl)-
CAS No.	84472-84-4
Molecular Formula	C30H27N5O5
Molecular Weight	537.57 g/mol
Synonyms	3'-Azido-2',3'-dideoxy-5'-O-trityluridine; 5'-O-(Triphenylmethyl)-3'-azido-2',3'-dideoxyuridine; 3'-Azido-3'-deoxy-5'-O-tritylthymidine (common misnomer); AZT-TPTr (abbreviation); 1-[(2R,5S)-5-Azido-5-({[trityloxy]methyl})tetrahydrofuran-2-yl]-2,4(1H,3H)-pyrimidinedione; 3'-N3-5'-O-DMT-2',3'-ddU (abbreviation); NSC 330836; Trityl-protected 3'-azido-2',3'-dideoxyuridine
EINECS	Contact for details

Quality Control

Our Uridine, 3'-Azido-2',3'-Dideoxy-5'-o-(Triphenylmethyl)- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, IR, MS), to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with complete chromatographic and spectral data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) in a cool, dry, and well-ventilated place. This compound is light-sensitive and easily oxidized; prolonged exposure to air, light, or ambient temperature should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.