Description

Oxmetidine is a selective histamine H2-receptor antagonist, a key pharmacologically active compound used in the research and development of therapeutic agents. Its primary value lies in its role as a critical intermediate and reference standard for investigating gastric acid secretion and related gastrointestinal disorders. This compound is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) focused on gastroenterology and receptor pharmacology.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of advanced H2-receptor antagonist drug candidates.
• Biochemical Research: Used as a reference standard in in vitro and in vivo studies to understand histamine H2-receptor binding and antagonism.
• API Development: A key starting material for the development and scale-up of new chemical entities targeting gastric acid-related conditions.
• Analytical Standard: Employed in HPLC, LC-MS, and NMR for method development, validation, and quality control of related pharmaceutical products.
• Academic & Clinical Research: Facilitates studies on the pathophysiology and treatment of peptic ulcers, gastroesophageal reflux disease (GERD), and Zollinger-Ellison syndrome.

Basic Information

Product Name	Oxmetidine
CAS No.	84455-52-7
Molecular Formula	C13H19N5O2S
Molecular Weight	309.39 g/mol
Synonyms	SK&F 92994; 2-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N2-ethylacetamidine; 1-[2-[[[2-[(Diaminomethylidene)amino]-1,3-thiazol-4-yl]methyl]sulfanyl]ethyl]-2-ethylguanidine; Guanidine, N-[2-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]ethyl]-N'-ethyl-; Oxmetidine Hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Oxmetidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support our products with a detailed Certificate of Analysis (COA) that includes results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.