Description

Esomeprazole CAS NO 119141-88-7 is the (S)-isomer of omeprazole, a proton pump inhibitor (PPI) that acts as a highly effective gastric acid secretion suppressant. This active pharmaceutical ingredient (API) is critical for the formulation of advanced gastroesophageal reflux disease (GERD) and peptic ulcer treatments, offering superior bioavailability and metabolic stability. It is an essential raw material for pharmaceutical manufacturers developing next-generation anti-ulcer and acid-related disorder medications, requiring consistent high purity and reliable supply chains for global drug production.

Application

• Pharmaceutical API: Primary use as the active ingredient in prescription medications for treating GERD, erosive esophagitis, and Zollinger-Ellison syndrome.
• Delayed-Release Formulations: Key component in enteric-coated tablets and capsules designed to release in the small intestine.
• Combination Drug Therapies: Used in fixed-dose combination products with antibiotics for Helicobacter pylori eradication regimens.
• Injectable Formulations: Serves as a base for developing intravenous solutions used in hospital settings for patients unable to take oral medication.
• Generic Drug Manufacturing: Core material for producing bioequivalent generic versions of branded esomeprazole products.
• Research & Development: Utilized in preclinical and clinical studies for developing new gastroprotective therapies and exploring novel drug delivery systems.

Basic Information

Product Name	Esomeprazole
CAS No.	119141-88-7
Molecular Formula	C17H19N3O3S
Molecular Weight	345.42 g/mol
Synonyms	(S)-Omeprazole; Esomeprazole Magnesium; Nexium® (Brand Name); (S)-5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole; Perprazole; H 199/18; Esomeprazole Sodium; Esoz
EINECS	Contact for details

Quality Control

Our Esomeprazole is manufactured under strict quality management systems, targeting compliance with major pharmacopoeial standards including USP, EP, and JP. Every batch undergoes comprehensive analytical testing, including chiral purity verification to ensure the specified (S)-isomer content. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results for identity, assay, related substances, residual solvents, and other critical parameters to guarantee it meets your stringent API specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.5%
Related Substances (HPLC)	Individual impurity: ≤ 0.15% Total impurities: ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.