Description

Nesosteine CAS NO 84233-61-4 is a synthetic mucolytic agent and expectorant, chemically known as (R)-2-amino-3-(2-hydroxyethylsulfanyl)propanoic acid. This compound is valued for its ability to reduce the viscosity of bronchial secretions, facilitating airway clearance and improving respiratory function. It is primarily utilized by pharmaceutical manufacturers in the development and production of advanced cough suppressants, expectorants, and treatments for chronic obstructive pulmonary disease (COPD) and bronchitis.

Application

• Pharmaceutical Active Ingredient (API): Core component in prescription and over-the-counter (OTC) mucolytic and expectorant medications.
• Respiratory Therapeutics: Formulated into syrups, tablets, and capsules for the management of acute and chronic respiratory conditions characterized by excessive, thick mucus.
• Veterinary Medicine: Used in veterinary pharmaceuticals for treating respiratory ailments in animals.
• Clinical Research: Serves as a reference standard and raw material in pharmacological studies and drug development pipelines.
• Combination Therapies: Incorporated into fixed-dose combination drugs alongside other active ingredients like bronchodilators or anti-inflammatory agents.

Basic Information

Product Name	Nesosteine
CAS No.	84233-61-4
Molecular Formula	C5H11NO3S
Molecular Weight	165.21 g/mol
Synonyms	(R)-2-Amino-3-(2-hydroxyethylthio)propanoic acid; (R)-2-Amino-3-[(2-hydroxyethyl)thio]propionic acid; Nesosteina; Nesosteinum; Erdosteine Impurity C; (R)-Erdosteine; L-Erdosteine; (2R)-2-Amino-3-(2-hydroxyethylsulfanyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Nesosteine is manufactured under strict quality management systems. Every batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling, to ensure it meets high-purity standards suitable for pharmaceutical use. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.