Description

Potassium Guaiacolsulfonate Hemihydrate is a white to off-white crystalline powder, primarily recognized for its role as an expectorant agent. This compound is valued for its ability to help loosen and clear mucus from the respiratory tract, making it a critical component in pharmaceutical formulations. It is essential for manufacturers in the pharmaceutical industry developing cough syrups, lozenges, and other respiratory medications. Consistent quality and reliable supply are paramount for ensuring the efficacy and safety of the final therapeutic products.

Application

• Pharmaceutical Active Ingredient (API): Primary use as an expectorant in prescription and over-the-counter (OTC) cough and cold medications.
• Syrup Formulations: Key component in liquid cough syrups and pediatric formulations for its mucolytic action.
• Tablet and Lozenge Production: Incorporated into solid oral dosage forms designed for respiratory relief.
• Veterinary Pharmaceuticals: Used in expectorant preparations for treating respiratory conditions in animals.
• Chemical Synthesis Intermediate: Serves as a building block or salt form in the synthesis of more complex sulfonated organic compounds.

Basic Information

Product Name	Potassium Guaiacolsulfonate Hemihydrate
CAS No.	16241-25-1
Molecular Formula	C7H7KO5S · 0.5H2O
Molecular Weight	249.30 g/mol (hemihydrate)
Synonyms	Potassium Guaiacolsulfonate; Guaiacol Potassium Sulfonate; Sulfogaiacol Potassium; Potassium 2-Methoxyphenol-4-sulfonate; Thiocol Potassium; Potassium Guaiacolsulfonate Sesquihydrate (common historical reference); Guaiacolsulfonic Acid Potassium Salt; 2-Methoxy-5-hydroxybenzenesulfonic Acid Potassium Salt
EINECS	240-327-8

Quality Control

Our Potassium Guaiacolsulfonate Hemihydrate is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmaceutical-grade expectations. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological attributes is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent caking or degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (Potassium)	Conforms to standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water (KF)	3.0% - 5.0% (hemihydrate)
Related Substances (HPLC)	Total impurities ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	Conforms to standard
Microbial Limits	Complies with Ph. Eur./USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.