Description

1-Formyl-Piperidine-4-Carbonyl Chloride is a versatile and highly reactive organic building block, specifically an acid chloride derivative of a piperidine carboxylic acid. Its primary value lies in its role as a key synthetic intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on active pharmaceutical ingredients (APIs), agrochemicals, and advanced material science.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly those containing the piperidine scaffold, which is prevalent in CNS-active and other therapeutic agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides where specific piperidine-based structures are required for bioactivity.
• Peptide Mimetics & PROTACs: Serves as a linker or core component in the design of peptide mimetics and Proteolysis Targeting Chimeras (PROTACs) for targeted protein degradation.
• Material Science Research: Employed in the development of specialty polymers, ligands for catalysis, and other functional organic materials.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences industry.

Basic Information

Product Name	1-Formyl-Piperidine-4-Carbonyl Chloride
CAS No.	84163-43-9
Molecular Formula	C7H10ClNO2
Molecular Weight	175.61 g/mol
Synonyms	4-(Chlorocarbonyl)-1-formylpiperidine; 1-Formylpiperidine-4-carboxylic acid chloride; 4-Piperidinecarbonyl chloride, 1-formyl-; 1-Formyl-4-piperidinecarbonyl chloride; 1-Formyl-4-piperidinecarboxylic acid chloride; 4-Carbamoyl-1-formylpiperidine hydrochloride (related); Piperidine-4-carbonyl chloride, 1-formyl-
EINECS	Contact for details

Quality Control

Every batch of 1-Formyl-Piperidine-4-Carbonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting purity (typically by HPLC/NMR), identity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.