Description

N6-Benzoyl-5'-o-(Dimethoxytrityl)-3'-Deoxyadenosine is a high-purity, protected nucleoside derivative essential for oligonucleotide synthesis. This compound serves as a critical building block for the solid-phase assembly of DNA and RNA sequences, enabling precise control over genetic material. It is primarily required by research institutions, diagnostic developers, and pharmaceutical companies engaged in antisense therapy development, PCR probe synthesis, and genomic research.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for automated solid-phase synthesis of DNA and RNA strands.
• Antisense and siRNA Therapeutics: Used in the research and development of gene-silencing drugs and therapeutic oligonucleotides.
• Diagnostic Probe Manufacturing: Essential for producing labeled probes used in PCR, FISH, and microarray technologies.
• Academic and Industrial Research: A fundamental reagent for studying nucleic acid chemistry, enzyme mechanisms, and molecular biology.
• Synthesis of Modified Nucleosides: Serves as an intermediate for creating nucleoside analogs with tailored properties.

Basic Information

Product Name	N6-Benzoyl-5'-o-(Dimethoxytrityl)-3'-Deoxyadenosine
CAS No.	84138-86-3
Molecular Formula	C38H35N5O6
Molecular Weight	657.72 g/mol
Synonyms	3'-Deoxyadenosine, N-benzoyl-5'-O-(4,4'-dimethoxytrityl)-; 5'-O-(4,4'-Dimethoxytrityl)-N-benzoyl-3'-deoxyadenosine; N6-Benzoyl-5'-O-DMT-3'-deoxyadenosine; DMT-dA(Bz) Amidite precursor; N-Bz-5'-O-DMT-3'-deoxyadenosine; 3'-dA(Bz) DMT; Protected 3'-Deoxyadenosine Derivative
EINECS	Contact for details

Quality Control

Our production of this protected nucleoside adheres to stringent quality protocols suitable for oligonucleotide synthesis and pharmaceutical research. Every batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, NMR, and mass spectrometry. We support compliance with relevant GMP and ISO 9001 standards for research-grade chemical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, freezer. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in acetonitrile, DMF, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.