Description

5-Iodo-5'-o-Pentanoyl-2'-Deoxyuridine is a chemically modified nucleoside analog, a key building block in advanced pharmaceutical and biochemical research. This compound is specifically engineered to introduce structural modifications into oligonucleotides, enabling the study of nucleic acid interactions and the development of novel therapeutic agents. It is essential for researchers and manufacturers in the fields of antiviral drug development, oncology research, and molecular diagnostics who require high-purity, specialized intermediates.

Application

• Antiviral Drug Intermediate: A critical precursor in the synthesis of novel nucleoside analog prodrugs targeting viral polymerases.
• Oncology Research: Used in the development of modified oligonucleotides for cancer therapy, including antisense and siRNA applications.
• Biochemical Probe Synthesis: Serves as a modified base for creating labeled probes to study DNA/RNA structure, function, and protein interactions.
• Prodrug Development: The pentanoyl ester group acts as a lipophilic promotiety, enhancing cell membrane permeability for improved drug delivery.
• Medicinal Chemistry Research: A versatile scaffold for structure-activity relationship (SAR) studies to optimize pharmacokinetic properties.
• Academic & Institutional Research: Fundamental tool in university and institutional labs for studying nucleic acid chemistry and enzymology.

Basic Information

Product Name	5-Iodo-5'-o-Pentanoyl-2'-Deoxyuridine
CAS No.	84052-69-7
Molecular Formula	C14H19IN2O6
Molecular Weight	438.22 g/mol
Synonyms	5-Iodo-2'-deoxy-5'-O-pentanoyluridine; 5-Iodo-5'-O-valeryl-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidine-2,4-dione 5'-pentanoate; 2'-Deoxy-5-iodo-5'-O-pentanoyluridine; 5-Iododeoxyuridine 5'-pentanoate ester; IDU 5'-pentanoate; 5-Iodo-5'-O-pentanoyl-dUrd
EINECS	Contact for details

Quality Control

Our 5-Iodo-5'-o-Pentanoyl-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with research and cGMP-grade material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.