Description

2,4(1H,3H)-Pyrimidinedione,1-[3-Hydroxy-4-(Hydroxymethyl)- Cyclopentyl ]-5-Iodo-, (1Alpha,3Beta,4Alpha)-(+ -)- is a specialized iodinated nucleoside analog with significant potential in advanced pharmaceutical research and development. This compound is valued for its role as a key synthetic intermediate or active pharmaceutical ingredient (API) precursor in the creation of novel antiviral and anticancer therapeutics. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and targeted drug discovery.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel antiviral drugs, particularly those targeting viral polymerases.
• Anticancer Agent Research: Investigated as a precursor for the development of nucleoside analog-based chemotherapeutic agents.
• Biochemical Research: Used in enzymatic studies and as a substrate analog to investigate nucleotide metabolism and related biological pathways.
• Radiopharmaceutical Precursor: The iodine moiety provides a potential handle for radiolabeling (e.g., with I-125 or I-131) for diagnostic imaging or therapeutic applications.
• Organic Synthesis Reference Standard: Employed as a high-purity standard for analytical method development and quality control in fine chemical production.
• Life Science Tool: Utilized in probe and assay development for studying DNA/RNA interactions and cellular processes.

Basic Information

Product Name	2,4(1H,3H)-Pyrimidinedione,1-[3-Hydroxy-4-(Hydroxymethyl)- Cyclopentyl ]-5-Iodo-, (1Alpha,3Beta,4Alpha)-(+ -)-
CAS No.	83967-03-7
Molecular Formula	C10H13IN2O4
Molecular Weight	352.13 g/mol
Synonyms	5-Iodo-1-[(1α,3β,4α)-3-hydroxy-4-(hydroxymethyl)cyclopentyl]pyrimidine-2,4(1H,3H)-dione; 1-[(1α,3β,4α)-3-Hydroxy-4-(hydroxymethyl)cyclopentyl]-5-iodouracil; 5-Iodo-1-carbocyclic uracil derivative; (±)-5-Iodo-carbodine; Iodinated carbocyclic nucleoside analog; 5-Iodo-C-Urd (abbrev.); Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high purity suitable for research and development purposes. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each batch, documenting identity, purity, and impurity profiles. We support compliance with ICH guidelines for stability and impurity characterization upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.