Description

2-Thiophenecarbonyl Chloride, 3-Fluoro- (9Ci) is a high-purity, reactive organosulfur building block essential for advanced chemical synthesis. This compound matters for its role as a key acylating agent, enabling the precise introduction of the 3-fluorothiophene-2-carbonyl moiety into complex molecular architectures. It is critically needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates. The compound, identified by CAS number 83933-21-5, is valued for its ability to drive innovation in drug discovery and specialty chemical manufacturing.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorinated thiophene scaffold can enhance biological activity and environmental profile.
• Material Science Research: Acts as a monomer or precursor for developing specialty polymers, liquid crystals, and organic electronic materials with unique optoelectronic properties.
• Chemical Biology & Proteomics: Employed as a reactive handle for labeling proteins or modifying biomolecules in probe development and bioconjugation strategies.
• Custom Synthesis & Contract Manufacturing: A key reagent for fine chemical and custom synthesis houses producing bespoke intermediates for client R&D programs.

Basic Information

Product Name	2-Thiophenecarbonyl Chloride, 3-Fluoro- (9Ci)
CAS No.	83933-21-5
Molecular Formula	C5H2ClFOS
Molecular Weight	164.58 g/mol
Synonyms	3-Fluorothiophene-2-carbonyl chloride; 3-Fluoro-2-thiophenecarbonyl chloride; 3-Fluorothiophene-2-carboxylic acid chloride; 2-Thiophenecarbonyl chloride, 3-fluoro-; 3-Fluorothiophene-2-carboxyl chloride; 3-Fluoro-2-thenoyl chloride; 3-Fluorothiophene-2-carbonylchloride
EINECS	Contact for details

Quality Control

Our 2-Thiophenecarbonyl Chloride, 3-Fluoro- (9Ci) is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee batch-to-batch consistency and support your regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and reacts with strong acids/organic solvents; therefore, it must be kept under an inert atmosphere (e.g., nitrogen or argon) and away from incompatible materials. Use appropriate corrosion-resistant storage equipment.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.