Description

cis-4-[[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methylthio]Aniline Dihydrochloride is a high-purity, complex organic intermediate of significant interest in advanced pharmaceutical synthesis. This compound is valued for its role as a critical building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting fungal and other infectious diseases. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for process development and scale-up activities.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the manufacture of antifungal and antimicrobial active pharmaceutical ingredients (APIs).
• Biochemical Research: Used in life science research for studying enzyme inhibition and developing novel therapeutic agents.
• Agrochemical Synthesis: Serves as an intermediate in the development of advanced crop protection agents and fungicides.
• Fine Chemical Production: Employed in custom synthesis and the production of specialized, high-value organic compounds.
• Process Chemistry & Scale-Up: Utilized in process optimization, route scouting, and pilot-scale manufacturing for new chemical entities.

Basic Information

Product Name	cis-4-[[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methylthio]Aniline Dihydrochloride
CAS No.	83929-39-9
Molecular Formula	C20H20Cl2N2O2S • 2HCl
Molecular Weight	503.28 g/mol
Synonyms	cis-4-[[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylthio]aniline dihydrochloride; 4-[[2-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methylthio]benzenamine dihydrochloride (cis-); Ketoconazole Intermediate; Ketoconazole Dihydrochloride Precursor; R 41400 Intermediate; Antifungal Synthesis Intermediate; 1,3-Dioxolane Aniline Derivative
EINECS	Contact for details

Quality Control

Our cis-4-[[2-(2,4-Dichlorophenyl)-2-(1H-Imidazol-1-Ylmethyl)-1,3-Dioxolan-4-Yl]Methylthio]Aniline Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.