Description

2,2-Difluoropropanoyl Chloride is a highly reactive fluorinated acid chloride building block. This compound is valued for its ability to introduce the difluoroacetyl moiety into target molecules, significantly altering their physicochemical and biological properties. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of advanced intermediates and active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting metabolic diseases and central nervous system (CNS) disorders.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluoroacetyl group enhances bioavailability and efficacy.
• Material Science Precursor: Serves as a monomer or modifying agent in the development of specialty polymers and fluorinated materials with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in academic and industrial R&D for Friedel-Crafts acylation, amide coupling, and esterification reactions to create complex fluorinated molecules.
• Ligand and Catalyst Development: Useful for synthesizing fluorinated ligands for metal complexes used in catalysis and imaging applications.

Basic Information

Product Name	2,2-Difluoropropanoyl Chloride
CAS No.	83698-73-1
Molecular Formula	C3H3ClF2O
Molecular Weight	128.51 g/mol
Synonyms	2,2-Difluoropropionyl Chloride; Difluoropropanoyl Chloride; Propanoyl Chloride, 2,2-difluoro-; α,α-Difluoropropionyl Chloride; 2,2-Difluoropropionic Acid Chloride
EINECS	Contact for details

Quality Control

Our 2,2-Difluoropropanoyl Chloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, NMR, and titration methods, to ensure high purity and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP and ISO standards for pharmaceutical and industrial applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C under an inert atmosphere (e.g., nitrogen or argon). Due to its hygroscopic and moisture-sensitive nature, containers must be kept sealed and allowed to reach room temperature before opening to prevent hydrolysis. Keep away from strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.