Description

3-Deaza-2'-Deoxyguanosine is a chemically modified nucleoside analog, a key building block in advanced biochemical research and pharmaceutical development. Its unique structure, where a nitrogen atom in the purine ring is replaced by a carbon atom, makes it a valuable tool for studying nucleic acid interactions and enzyme mechanisms. This compound is essential for researchers and developers in the fields of antiviral drug discovery, oligonucleotide synthesis, and molecular biology, where precise structural modifications are required to probe biological function and develop novel therapeutics.

Application

• Antiviral and Anticancer Research: Serves as a critical precursor or intermediate in the synthesis of nucleoside analogs designed to inhibit viral replication or tumor cell growth.
• Oligonucleotide Synthesis: Used to incorporate modified bases into DNA strands for applications in diagnostics, gene silencing (e.g., antisense oligonucleotides), and basic research on nucleic acid structure and stability.
• Enzyme Mechanism Studies: Acts as a substrate or inhibitor for enzymes like nucleoside kinases and polymerases to elucidate catalytic pathways and substrate specificity.
• Biochemical Probe Development: Employed in the creation of labeled or tagged nucleosides for tracking metabolic pathways or imaging within biological systems.
• Pharmaceutical Intermediate: A high-purity building block in the multi-step synthesis of potential therapeutic agents targeting various diseases.

Basic Information

Item	Details
Product Name	3-Deaza-2'-Deoxyguanosine
CAS No.	83587-63-7
Molecular Formula	C11H14N4O4
Molecular Weight	266.25 g/mol
Synonyms	3-Deaza-2'-deoxyguanosine; 2'-Deoxy-3-deazaguanosine; 9-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-imidazo[4,5-c]pyridin-4-amine; 3-Deaza-dG; 3-Deaza-2'-deoxy-Guanosine; 4-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-imidazo[4,5-c]pyridine
EINECS	Contact for details

Quality Control

Our 3-Deaza-2'-Deoxyguanosine is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.