Description

P(1),P(2)-Bis(6-Mercaptopurine-9 β-Ribofuranoside)-5'-Pyrophosphate is a specialized nucleotide analog derivative of 6-mercaptopurine, a key compound in biochemical research and pharmaceutical development. This molecule is significant for its role as a potential prodrug or metabolic intermediate, offering targeted activity in nucleotide metabolism pathways. It is primarily required by researchers and manufacturers in the pharmaceutical and biotechnology sectors for applications in oncology research, antiviral studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate or reference standard in the synthesis and study of novel chemotherapeutic agents targeting purine metabolism.
• Oncology Studies: Used in biochemical and pharmacological research to investigate mechanisms of action for leukemia and autoimmune disease treatments, given its relation to 6-mercaptopurine.
• Antiviral Agent Development: Explored for its potential as a nucleotide analog in the design of antiviral drugs, where modified nucleosides can inhibit viral replication.
• Enzymology & Biochemistry: Acts as a substrate or inhibitor in enzymatic assays to study the function of kinases, phosphorylases, and other enzymes involved in nucleotide synthesis and salvage pathways.
• Metabolite Analysis: Employed as an analytical standard in mass spectrometry (LC-MS/MS) and HPLC for the quantification of mercaptopurine metabolites in pharmacokinetic and bioanalytical studies.
• Prodrug Synthesis: Investigated for the design of prodrugs aimed at improving the bioavailability and reducing the toxicity of thiopurine-based therapies.

Basic Information

Product Name	P(1),P(2)-Bis(6-Mercaptopurine-9 β-Ribofuranoside)-5'-Pyrophosphate
CAS No.	83385-99-3
Molecular Formula	C20H24N8O13P2S2
Molecular Weight	718.52 g/mol
Synonyms	6-Mercaptopurine Riboside Pyrophosphate Dimer; 6-MP Riboside Pyrophosphate Dimer; 6-Thioinosine Pyrophosphate Dimer; P1,P2-Bis(6-thioinosine)-5'-pyrophosphate; 6-Thioguanosine Pyrophosphate Dimer (related analog); Bis(6-mercaptopurine riboside) pyrophosphate; 9-β-D-Ribofuranosyl-6-mercaptopurine 5'-pyrophosphate dimer
EINECS	Contact for details

Quality Control

Our P(1),P(2)-Bis(6-Mercaptopurine-9 β-Ribofuranoside)-5'-Pyrophosphate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, mass spectrometry for identity confirmation, and NMR for structural verification, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data and specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under argon or nitrogen. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.