Description

P(1),P(2)-Bis(O(2'),O(3')-Dihexanoyl-6-Mercaptopurine-9 β-Ribofuranoside)-5'-Pyrophosphate is a sophisticated nucleotide analog derivative, designed for advanced biochemical and pharmaceutical research. This compound is a critical intermediate for developing targeted prodrugs and nucleotide-based therapeutics, offering a high degree of functionalization for site-specific delivery. It is primarily utilized by research institutions and pharmaceutical developers focused on oncology, antiviral agents, and nucleotide metabolism studies.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel nucleotide prodrugs and antimetabolite therapies.
• Oncology Research: Investigated for the development of targeted chemotherapeutic agents, particularly in leukemia and solid tumor research.
• Antiviral Drug Development: Serves as a precursor in the design of nucleoside analogs with potential activity against viral polymerases.
• Biochemical Tool: Used in enzymatic studies to understand the mechanisms of nucleotide incorporation and pyrophosphate release.
• Prodrug Synthesis: The dihexanoyl groups enhance lipophilicity, making it a candidate for improving cellular uptake and bioavailability in prodrug strategies.
• Academic & Contract Research: Employed in university and CRO laboratories for cutting-edge medicinal chemistry and pharmacology projects.

Basic Information

Product Name	P(1),P(2)-Bis(O(2'),O(3')-Dihexanoyl-6-Mercaptopurine-9 β-Ribofuranoside)-5'-Pyrophosphate
CAS No.	83385-95-9
Molecular Formula	C44H56N8O18P2S2
Molecular Weight	1118.06 g/mol
Synonyms	6-Mercaptopurine-9-β-D-ribofuranoside 2',3'-Dihexanoate 5'-(Trihydrogen Diphosphate) P1,P2-Bis(ester); 6-MP Riboside Dihexanoyl Pyrophosphate; Bis(2',3'-di-O-hexanoyl-6-mercaptopurine riboside) 5'-pyrophosphate; 6-Thioinosine 2',3'-Dihexanoate 5'-Diphosphate Dimer; Nucleotide Prodrug Intermediate 83385-95-9; 6-TG Riboside Esterified Pyrophosphate Derivative
EINECS	Contact for details

Quality Control

Every batch of P(1),P(2)-Bis(O(2'),O(3')-Dihexanoyl-6-Mercaptopurine-9 β-Ribofuranoside)-5'-Pyrophosphate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation, to ensure identity and consistency for your critical research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, and custom purity grades (e.g., >95%, >98%) are available upon request to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); therefore, containers must be sealed under an inert atmosphere (argon or nitrogen) after each use and allowed to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.