Description

5-(2-Bromovinyl)-2'-Deoxyuridylate is a modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a crucial intermediate and building block for the synthesis of novel antiviral and anticancer agents. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in the development of nucleoside-based therapeutics. Its unique structure allows for targeted modifications in drug discovery programs aimed at viral and oncological targets.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced antiviral and anticancer nucleoside analogs.
• Antiviral Research: Used in the development of compounds targeting herpesviruses (e.g., HSV, VZV) and other DNA viruses.
• Oncology Research: Serves as a precursor for prodrugs and targeted therapies designed to inhibit tumor cell proliferation.
• Biochemical Research: Employed in enzymatic studies and as a substrate or inhibitor for thymidine kinase and related enzymes.
• Medicinal Chemistry: A versatile scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Radiopharmaceuticals: Potential precursor for the development of radiolabeled diagnostic or therapeutic agents.

Basic Information

Product Name	5-(2-Bromovinyl)-2'-Deoxyuridylate
CAS No.	83378-41-0
Molecular Formula	C11H12BrN2O8P
Molecular Weight	411.10 g/mol
Synonyms	5-(2-Bromovinyl)-2'-deoxyuridine 5'-monophosphate; (E)-5-(2-Bromovinyl)-2'-deoxyuridine 5'-phosphate; BVDU-MP; Brivudin monophosphate; 5-(2-Bromovinyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione 5'-(dihydrogen phosphate); 5-(2-Bromovinyl)-2'-deoxyuridylic acid; (E)-5-(2-Bromoethenyl)-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4(1H,3H)-dione 5'-phosphate
EINECS	Contact for details

Quality Control

Our 5-(2-Bromovinyl)-2'-Deoxyuridylate is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot undergoes comprehensive analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with every shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.