Description

Rac-trans-Ketoconazole CAS NO 83374-59-8 is a synthetic antifungal compound belonging to the imidazole class, serving as a key stereoisomeric form of the active pharmaceutical ingredient ketoconazole. This high-purity chemical intermediate is critical for research and development in pharmaceutical synthesis, particularly for investigating structure-activity relationships and metabolic pathways. It is primarily utilized by pharmaceutical R&D laboratories, analytical reference standard producers, and manufacturers of active pharmaceutical ingredients (APIs) requiring precise stereochemical control.

Application

• Pharmaceutical Reference Standard: Used as an analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of ketoconazole-based products.
• Active Pharmaceutical Ingredient (API) Research: Serves as a critical intermediate in the R&D of antifungal drug candidates, enabling studies on stereochemistry's impact on efficacy and safety.
• Metabolite and Impurity Profiling: Employed in pharmacokinetic and toxicology studies to identify and quantify stereoisomeric metabolites and related substances.
• Biochemical Research: Used as a tool compound in vitro to study the inhibition of fungal cytochrome P450 enzymes, specifically lanosterol 14α-demethylase.
• Process Chemistry Development: Acts as a model compound for developing and optimizing stereoselective synthesis and purification processes in scale-up laboratories.

Basic Information

Product Name	Rac-trans-Ketoconazole
CAS No.	83374-59-8
Molecular Formula	C₂₆H₂₈Cl₂N₄O₄
Molecular Weight	531.43 g/mol
Synonyms	trans-Ketoconazole; (±)-trans-Ketoconazole; rac-trans-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine; Ketoconazole trans-isomer; Ketoconazole Racemic trans Form; NSC 759985; (2R*,4S*)-Ketoconazole and (2S*,4R*)-Ketoconazole Mixture
EINECS	Contact for details

Quality Control

Our Rac-trans-Ketoconazole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods, purity assay by HPLC, and control of specified impurities. A Certificate of Analysis (COA) detailing all test results is provided to ensure traceability and compliance with your research or quality specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.