Description

[(2R,3R,4S,5R)-5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxy-[(2R)-2,3-Dioctadecanoyloxypropoxy]Phosphinic Acid is a sophisticated phospholipid-conjugated nucleoside derivative, representing a key intermediate in advanced pharmaceutical and biochemical research. This compound is critical for the development of novel drug delivery systems, particularly in creating liposomal formulations for targeted therapeutic applications. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of nucleotide-based therapeutics, prodrugs, and specialized lipid nanoparticles.

Application

• Lipid Nanoparticle (LNP) Formulation: A critical component in the synthesis of ionizable cationic lipids for mRNA and siRNA delivery systems.
• Prodrug Development: Serves as a phospholipid prodrug conjugate for nucleoside analogs, enhancing cellular uptake and bioavailability.
• Antiviral Research: Investigated as a potential carrier for antiviral nucleosides to improve their pharmacokinetic profiles.
• Cancer Therapeutics: Used in research for targeted delivery of chemotherapeutic agents via liposomal encapsulation.
• Bioconjugation & Labeling: Acts as a versatile linker for attaching bioactive molecules to lipid membranes or nanoparticles.
• Membrane Biochemistry Studies: Employed as a synthetic analog to study the incorporation and behavior of modified phospholipids in cellular membranes.

Basic Information

Item	Details
Product Name	[(2R,3R,4S,5R)-5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxy-[(2R)-2,3-Dioctadecanoyloxypropoxy]Phosphinic Acid
CAS No.	83214-11-3
Molecular Formula	C₅₃H₉₉N₄O₁₇P₂
Molecular Weight	1125.30 g/mol
Synonyms	1,2-Distearoyl-sn-glycero-3-cytidine diphosphate; Cytidine 5'-diphosphate-1,2-dioctadecanoyl-sn-glycerol; CDP-Distearoylglycerol; CDP-DSG; Cytidine diphosphate diacylglycerol (C18:0); CDP-DAG (C18:0); Phospholipid-nucleoside conjugate; Cytidine-5'-diphospho-1,2-distearoyl-sn-glycerol
EINECS	Contact for details

Quality Control

Our [(2R,3R,4S,5R)-5-(4-Amino-2-Oxo-Pyrimidin-1-Yl)-3,4-Dihydroxy-Oxolan-2-Yl]Methoxy-Hydroxy-Phosphoryl]Oxy-[(2R)-2,3-Dioctadecanoyloxypropoxy]Phosphinic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and MS for identity verification, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with full analytical data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.