Description

Rp-Ttp-α-S/Rp-Dttp-α-S Sodium Salt is a high-purity, modified nucleoside triphosphate analog used in advanced biochemical research and synthesis. This compound is critical for applications requiring precise control over nucleic acid structure and function, such as the study of enzyme mechanisms and the development of novel therapeutic agents. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies specializing in molecular biology, enzymology, and oligonucleotide synthesis.

Application

• Enzymology Studies: Used as a substrate or inhibitor in kinetic studies of DNA/RNA polymerases, reverse transcriptases, and other nucleic acid-processing enzymes.
• Oligonucleotide Synthesis: Serves as a building block for the solid-phase synthesis of modified oligonucleotides with specific stereochemical configurations.
• Structural Biology: Incorporated into nucleic acids for X-ray crystallography or NMR studies to investigate protein-nucleic acid interactions and conformational dynamics.
• Antiviral & Anticancer Research: Investigated for its potential as a chain terminator or modulator in the development of nucleotide-based prodrugs and therapeutic agents.
• Diagnostic Probe Development: Utilized in the creation of labeled probes for sensitive detection assays, including next-generation sequencing platforms.
• Biochemical Assay Development: Acts as a key reagent in high-throughput screening (HTS) assays to identify novel enzyme inhibitors or activators.

Basic Information

Product Name	Rp-Ttp-α-S / Rp-Dttp-α-S Sodium Salt
CAS No.	83199-35-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rp-α-Thiotriphosphate; Rp-Deoxythymidine 5'-(α-Thiotriphosphate), Sodium Salt; Rp-dTTPαS; Sp-5'-O-{[(Rp)-α-Thio]triphosphato}thymidine; (Rp)-2'-Deoxythymidine-5'-O-(1-thiotriphosphate) Trisodium Salt; (Rp)-dTTPαS; Thymidine 5'-(α-thiotriphosphate), Rp-isomer; Modified dTTP analog
EINECS	Contact for details

Quality Control

Our Rp-Ttp-α-S/Rp-Dttp-α-S Sodium Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and stereochemical integrity, NMR for structural confirmation, and ICP-MS for elemental analysis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided to ensure compliance with rigorous research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Rp-Diastereomeric Excess	≥ 98%
Water Content (KF)	≤ 5.0%
Biological Activity	Tested in standard polymerase assay

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.