Description

Rp-Ttp-α-S/Rp-Dttp-α-S Sodium Salt is a high-purity nucleotide analog derivative, a critical building block in advanced biochemical research and pharmaceutical development. This compound is essential for the synthesis and study of modified oligonucleotides, enabling precise manipulation of genetic material. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in antisense therapy, PCR applications, and next-generation sequencing (NGS) technologies.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Therapeutics: Used in the development of therapeutic oligonucleotides designed to target specific mRNA sequences.
• Molecular Diagnostics: Incorporation into probes and primers for PCR, qPCR, and other amplification-based diagnostic assays to enhance specificity.
• Next-Generation Sequencing (NGS): Serves as a substrate or terminator in sequencing-by-synthesis platforms to study genetic variations.
• Biochemical Research: A vital tool for studying enzyme mechanisms, nucleic acid interactions, and polymerase fidelity.
• Labeling & Detection: Can be used to introduce tags or modifications for the detection and tracking of nucleic acids.

Basic Information

Product Name	Rp-Ttp-α-S/Rp-Dttp-α-S Sodium Salt
CAS No.	83199-32-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Rp-α-Thiotriphosphate Sodium Salt; 2'-Deoxyadenosine 5'-(α-thio)triphosphate, Rp-isomer, Sodium Salt; dATPαS (Rp); Rp-dATPαS; Adenosine 5'-(α-thiotriphosphate), 2'-deoxy-, Rp diastereomer, sodium salt; Sp-2'-deoxyadenosine-5'-O-(1-thiotriphosphate) (incorrect but common alias); Rp isomer of 2'-deoxyadenosine 5'-O-(1-thiotriphosphate)
EINECS	Contact for details

Quality Control

Every batch of Rp-Ttp-α-S/Rp-Dttp-α-S Sodium Salt is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and diastereomeric excess meet the exacting standards required for life science research. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results from HPLC, NMR, and MS analysis.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Diastereomeric Purity (Rp-isomer)	≥ 98%
Water Content (KF)	≤ 5.0%
Biological Activity	Suitable for enzymatic incorporation

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.