Description

[R,(+)]-2-(Benzyloxy)Propionyl Chloride is a high-purity chiral building block and acid chloride reagent essential for advanced organic synthesis. Its primary value lies in its role as a key intermediate for introducing the (R)-2-(benzyloxy)propionyl moiety, a crucial structural element in the development of active pharmaceutical ingredients (APIs) and fine chemicals. This compound is critically needed by research and development chemists, process development teams, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex, stereochemically defined molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of enantiomerically pure APIs, particularly in antibiotic and antiviral drug development.
• Peptide Chemistry: Used as an activated ester precursor or acylating agent for the selective protection and modification of amino acids and peptides.
• Asymmetric Synthesis: Serves as a starting material or reagent in catalytic asymmetric transformations to create chiral centers with high enantiomeric excess.
• Ligand and Catalyst Preparation: Employed in the synthesis of chiral ligands for transition metal catalysis and organocatalysts.
• Agrochemical Research: Used in the development of chiral herbicides, fungicides, and plant growth regulators.
• Material Science: A monomer or modifying agent for creating specialized polymers with tailored optical or mechanical properties.

Basic Information

Product Name	[R,(+)]-2-(Benzyloxy)Propionyl Chloride
CAS No.	82977-93-3
Molecular Formula	C10H11ClO2
Molecular Weight	198.65 g/mol
Synonyms	(R)-(+)-2-(Benzyloxy)propionyl chloride; (R)-2-Benzyloxypropionyl chloride; D-2-(Benzyloxy)propionyl chloride; (R)-O-Benzyl-lactoyl chloride; (2R)-2-(Phenylmethoxy)propanoyl chloride; (R)-α-(Benzyloxy)propionyl chloride; (+)-2-Benzyloxypropionic acid chloride
EINECS	Contact for details

Quality Control

Our [R,(+)]-2-(Benzyloxy)Propionyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming specifications for identity, purity, enantiomeric excess, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and reacts vigorously with water, strong bases, and alcohols. Containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (Karl Fischer)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.