Description

6-Diethylcarbamyloxy-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically a protected form of 2'-deoxyguanosine. This compound is of significant value as a key synthetic intermediate and building block in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of nucleoside chemistry, oligonucleotide synthesis, and prodrug development, particularly for creating novel antiviral and anticancer agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of modified oligonucleotides and nucleotide analogs.
• Antiviral Drug Research: Used in the development of prodrugs and active pharmaceutical ingredients (APIs) targeting viral polymerases.
• Anticancer Agent Development: Serves as a precursor in the creation of nucleoside-based chemotherapeutic compounds.
• Oligonucleotide Synthesis: Employed in solid-phase and solution-phase synthesis to introduce protected guanine bases into DNA sequences.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA replication and repair.
• Prodrug Design: The diethylcarbamyloxy protecting group makes it valuable for designing bioreversible derivatives to enhance drug delivery and bioavailability.

Basic Information

Product Name	6-Diethylcarbamyloxy-2'-Deoxyguanosine
CAS No.	82721-27-5
Molecular Formula	C₁₅H₂₂N₆O₆
Molecular Weight	382.37 g/mol
Synonyms	2'-Deoxy-N6-(diethylcarbamoyl)guanosine; 6-O-(Diethylcarbamoyl)-2'-deoxyguanosine; 2'-Deoxyguanosine, 6-(diethylcarbamoyl)-; N6-Diethylcarbamoyl-2'-deoxyguanosine; dG(N6-Et2); Protected 2'-Deoxyguanosine; N6-(Diethylcarbamoyl)-2'-deoxyguanosine
EINECS	Contact for details

Quality Control

Our 6-Diethylcarbamyloxy-2'-Deoxyguanosine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.