Description

O(4)-Butylthymidine CAS NO 82543-41-7 is a chemically modified nucleoside derivative, specifically a thymidine analog with a butyl group at the O4 position. This structural modification makes it a valuable building block and intermediate in advanced organic synthesis and pharmaceutical research. It is primarily utilized by research scientists and process chemists in the development of novel therapeutic agents, diagnostic probes, and biochemical tools. The compound's defined structure is critical for studies in medicinal chemistry, particularly in the design of antiviral and anticancer nucleotide analogs.

Application

• Pharmaceutical Intermediate: Key synthetic precursor in the research and development of novel antiviral and anticancer nucleotide-based drugs.
• Biochemical Research: Used as a modified nucleoside substrate in enzymatic studies and for investigating DNA/RNA metabolism and repair mechanisms.
• Probe and Diagnostic Development: Serves as a building block for synthesizing labeled nucleotides or molecular probes used in diagnostic assays and imaging.
• Antisense Oligonucleotide Synthesis: An intermediate in the preparation of modified oligonucleotides for antisense and gene silencing applications.
• Medicinal Chemistry Library: A valuable scaffold for creating diverse compound libraries to screen for new biological activities.
• Academic and Institutional Research: Employed in university and institutional labs for fundamental research in nucleic acid chemistry and biology.

Basic Information

Product Name	O(4)-Butylthymidine
CAS No.	82543-41-7
Molecular Formula	C14H22N2O5
Molecular Weight	298.34 g/mol
Synonyms	4-O-Butylthymidine; Thymidine, 4-O-butyl-; 1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-butoxy-5-methylpyrimidin-2(1H)-one; 4-Butoxythymidine; O4-Butylthymidine; 1-(2-Deoxy-β-D-ribofuranosyl)-4-butoxy-5-methyl-2(1H)-pyrimidinone; Butylthymidine; 2'-Deoxy-4-O-butylthymidine
EINECS	Contact for details

Quality Control

Our O(4)-Butylthymidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications. Our quality commitment supports applications requiring high-purity, well-characterized chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.