Description

O(2)-Butylthymidine is a chemically modified nucleoside derivative, specifically a thymidine analog with a butyl group at the 2'-O position. This modification is crucial for imparting unique properties such as enhanced lipophilicity and metabolic stability, making it a valuable building block in advanced research and development. It is primarily utilized by pharmaceutical researchers, biochemists, and diagnostic developers working on oligonucleotide synthesis, prodrug design, and antiviral or anticancer therapeutic agents.

Application

• Oligonucleotide Synthesis: A key phosphoramidite monomer for the solid-phase synthesis of modified antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs).
• Prodrug Development: Serves as a lipophilic prodrug moiety to improve the cellular uptake and bioavailability of nucleoside-based antiviral and anticancer drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the function of polymerases, nucleotidyltransferases, and other nucleic acid-metabolizing enzymes.
• Diagnostic Probe Design: Incorporated into nucleic acid probes to enhance binding affinity or alter hybridization kinetics for improved diagnostic assay performance.
• Medicinal Chemistry: A versatile intermediate for the synthesis of novel nucleoside analogs with potential therapeutic applications.
• Stable Isotope Labeling: Can be used as a precursor for the synthesis of isotopically labeled compounds for metabolic tracing and pharmacokinetic studies.

Basic Information

Item	Detail
Product Name	O(2)-Butylthymidine
CAS No.	82543-40-6
Molecular Formula	C14H22N2O5
Molecular Weight	298.34 g/mol
Synonyms	2'-O-Butylthymidine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)-2-(2-methylbutoxy)oxolan-2-yl]-5-methylpyrimidine-2,4-dione; 5-Methyl-2'-O-butyluridine; Thymidine, 2'-O-butyl-; 2'-O-n-Butylthymidine; O2-Butylthymidine; 2'-Butyloxythymidine
EINECS	Contact for details

Quality Control

Every batch of O(2)-Butylthymidine is manufactured under strict quality management systems. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed results from HPLC, NMR, and mass spectrometry to verify identity, purity, and conformity to customer specifications. Our quality commitment ensures material suitable for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.