Description

O(6)-Butylguanosine is a chemically modified nucleoside derivative where a butyl group is specifically attached to the O6 position of the guanosine base. This targeted modification is of significant interest in biochemical and pharmaceutical research, particularly in the study of DNA alkylation, repair mechanisms, and as a potential building block for novel therapeutic agents. It serves as a critical reference standard and synthetic intermediate for researchers and developers in the fields of oncology, molecular biology, and medicinal chemistry.

Application

• Biochemical Research: Used as a key reference compound and substrate in studies of DNA damage, repair enzymes like O6-alkylguanine-DNA alkyltransferase (AGT), and mutagenesis.
• Medicinal Chemistry: Serves as a crucial synthetic intermediate or precursor in the development of novel nucleoside-based therapeutics and targeted cancer drugs.
• Oncology Studies: Employed in research focused on understanding the mechanisms of alkylating chemotherapeutic agents and developing resistance-modulating strategies.
• Enzyme Inhibition Assays: Acts as a substrate or inhibitor in high-throughput screening assays to identify and characterize new enzyme inhibitors.
• Analytical Standard: Provides a high-purity standard for analytical methods such as HPLC, LC-MS, and NMR in quality control and metabolic studies.
• Academic & Institutional Research: Fundamental tool for universities and research institutes exploring nucleic acid chemistry and carcinogenesis.

Basic Information

Product Name	O(6)-Butylguanosine
CAS No.	82543-37-1
Molecular Formula	C14H21N5O5
Molecular Weight	339.35 g/mol
Synonyms	9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-butyloxy-9H-purin-2-amine; 6-O-Butylguanosine; O6-Butylguanosine; Guanosine, O6-butyl-; 6-Butoxyguanosine; 2-Amino-6-butoxy-9-β-D-ribofuranosylpurine; NSC 341984
EINECS	Contact for details

Quality Control

Our O(6)-Butylguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and moisture to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and consistent quality for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.