Description

5-Isothiocyanato-1-Naphthalene Azide is a specialized bifunctional chemical reagent that combines an isothiocyanate group with a photoactivatable azide moiety. This unique structure makes it a critical tool for advanced bioconjugation and photoaffinity labeling applications, enabling the study of biomolecular interactions. It is primarily utilized by researchers and manufacturers in the fields of pharmaceutical development, proteomics, and chemical biology who require precise, covalent crosslinking under controlled conditions.

Application

• Photoaffinity Labeling Probe: Used to identify and study transient or weak protein-ligand interactions, receptor binding sites, and enzyme active sites upon UV light activation.
• Bioconjugation Reagent: Serves as a heterobifunctional crosslinker for covalently attaching molecules (e.g., fluorophores, peptides, drugs) to proteins, antibodies, or other biomolecules via the isothiocyanate group.
• Chemical Biology Research: A key reagent for developing activity-based probes (ABPs) to profile enzyme function and for mapping protein-protein interaction networks in complex biological systems.
• Pharmaceutical R&D: Employed in drug discovery for target identification, validation, and in the development of antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Material Surface Functionalization: Used to introduce reactive groups onto surfaces (e.g., nanoparticles, biosensors) for subsequent immobilization of biological entities.

Basic Information

Product Name	5-Isothiocyanato-1-Naphthalene Azide
CAS No.	82516-84-5
Molecular Formula	C11H6N4S
Molecular Weight	226.26 g/mol
Synonyms	1-Azido-5-isothiocyanatonaphthalene; 5-Isothiocyanatonaphthalene-1-azide; 1-Azido-5-isothiocyanato-naphthalene; Naphthalene-1-azide, 5-isothiocyanato-; 5-Azido-1-isothiocyanatonaphthalene (isomer); 5-Isothiocyanato-1-azidonaphthalene; Photoactivatable isothiocyanate crosslinker; Heterobifunctional naphthyl azide reagent
EINECS	Contact for details

Quality Control

Our 5-Isothiocyanato-1-Naphthalene Azide is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We support compliance with research and development standards, and specifications can be tailored to meet specific project requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere when appropriate to maximize shelf life. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.