Description

Triethyl Phosphonoacetate-2-13C is a stable isotope-labeled analog of triethyl phosphonoacetate, where the carbon-2 position is enriched with the 13C isotope. This compound is a critical reagent in the synthesis of isotopically labeled compounds, enabling advanced research and development in analytical chemistry and life sciences. It is primarily utilized by researchers and process chemists in pharmaceutical development, agrochemical research, and metabolic studies who require precise isotopic labeling for tracer experiments, NMR spectroscopy, and mass spectrometry.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the preparation of 13C-labeled active pharmaceutical ingredients (APIs) and drug metabolites for pharmacokinetic and pharmacodynamic studies.
• Agrochemical Research: Used in the development of isotopically labeled pesticides, herbicides, and plant growth regulators to study environmental fate, degradation pathways, and metabolic processes.
• Metabolic Pathway Tracing: Essential for creating 13C-labeled probes in biochemical research to trace metabolic fluxes and elucidate complex biological pathways using NMR or LC-MS.
• Analytical Standard Development: Serves as a high-purity reference standard and internal standard for quantitative analysis by mass spectrometry, improving accuracy and reliability in assays.
• Organic Synthesis & Methodology: Employed in Horner-Wadsworth-Emmons (HWE) olefination reactions to introduce a 13C-labeled vinyl group or acrylate moiety into complex molecular architectures.
• Material Science Research: Potential precursor for synthesizing specialty polymers or organic electronic materials with specific isotopic labeling for studying structure-property relationships.

Basic Information

Product Name	Triethyl Phosphonoacetate-2-13C
CAS No.	82426-28-6
Molecular Formula	C8H1713CO5P
Molecular Weight	226.18 g/mol (for 13C1 isotopologue)
Synonyms	(Triethoxyphosphoryl)acetic-2-13C acid ethyl ester; Diethyl (ethoxycarbonylmethyl-2-13C)phosphonate; Ethyl (diethoxyphosphoryl)acetate-2-13C; Triethyl (2-13C)phosphonoacetate; TEPA-2-13C; [2-13C]-Triethyl phosphonoacetate; (Carbethoxymethyl-2-13C)phosphonic acid diethyl ester; Diethyl (carbethoxymethyl-2-13C)phosphonate
EINECS	Contact for details

Quality Control

Our Triethyl Phosphonoacetate-2-13C is manufactured under strict quality systems to ensure high isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity (by NMR and HPLC), and identity confirmation. We adhere to relevant industry guidelines for stable isotope-labeled compounds to ensure batch-to-batch consistency and reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99% at C-2 position
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.