Description

6-(Maleimido)Hexanoic Acid Chloride is a heterobifunctional crosslinking reagent featuring a maleimide group and an acid chloride functionality. This compound is critical for creating stable, covalent bonds between amine-containing molecules and thiol-containing molecules under mild conditions. It is primarily needed by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and advanced materials science for surface functionalization.

Application

• Bioconjugation and ADC Linker Chemistry: Serves as a key intermediate for synthesizing cleavable or non-cleavable linkers to conjugate cytotoxic drugs to monoclonal antibodies.
• Protein and Peptide Modification: Used to site-specifically label proteins, enzymes, or peptides with fluorescent dyes, PEG chains, or other probes via thiol-maleimide chemistry.
• Surface Functionalization: Enables the covalent attachment of biomolecules (like proteins or DNA) to amine-functionalized surfaces such as nanoparticles, microarrays, or sensor chips.
• Polymer Synthesis: Acts as a reactive monomer or end-group modifier for creating functional polymers with pendant maleimide groups for further coupling.
• Diagnostic Reagent Development: Utilized in the production of immunoassay components and diagnostic conjugates requiring stable thioether linkages.
• Hydrogel and Biomaterial Fabrication: Incorporated into polymer networks to introduce reactive handles for cell adhesion ligands or growth factors.

Basic Information

Product Name	6-(Maleimido)Hexanoic Acid Chloride
CAS No.	82333-93-5
Molecular Formula	C10H12ClNO3
Molecular Weight	229.66 g/mol
Synonyms	6-Maleimidocaproyl Chloride; N-(6-Chloro-6-oxohexyl)maleimide; Maleimidocaproic Acid Chloride; 6-Maleimidohexanoyl Chloride; 6-(Maleimidoyl)hexanoic Acid Chloride; 6-Maleimidocaproyl Chloride; 6-Maleimido-1-hexanoic Acid Chloride; 6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoyl Chloride
EINECS	Contact for details

Quality Control

Our 6-(Maleimido)Hexanoic Acid Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under an inert atmosphere (e.g., argon or nitrogen). Due to its hygroscopic and moisture-sensitive nature, the container must be allowed to reach room temperature before opening to prevent condensation and hydrolysis. Keep away from strong bases and amines.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	≥ 90% (by titration)
Solubility	Soluble in dichloromethane, DMF, THF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.