Description

Tetracenomycin A2 is a significant member of the tetracenomycin class of aromatic polyketide antibiotics, identified by CAS NO 82277-62-1. This compound serves as a crucial intermediate and reference standard in the research and development of novel antibacterial agents, particularly against Gram-positive bacteria. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on antibiotic discovery and biosynthesis pathway studies.

Application

• Antibiotic Research & Development: As a key intermediate in the biosynthesis of tetracyclines and related compounds, it is used to study structure-activity relationships and develop new antimicrobial therapies.
• Biochemical Pathway Analysis: Serves as a critical standard for investigating the enzymatic mechanisms of polyketide synthases (PKS) in bacteria.
• Pharmaceutical Reference Standard: Used for the qualitative and quantitative analysis (HPLC, LC-MS) of antibiotic preparations and fermentation broths in quality control laboratories.
• Academic Research: Employed in microbiology and medicinal chemistry studies to understand the mode of action and resistance mechanisms of polyketide antibiotics.
• Biosynthesis Studies: Acts as a probe compound for genetic and metabolic engineering aimed at optimizing the yield of valuable antibiotic derivatives.

Basic Information

Product Name	Tetracenomycin A2
CAS No.	82277-62-1
Molecular Formula	C22H16O10
Molecular Weight	440.36 g/mol
Synonyms	Tetracenomycin A2; Tcm A2; 4,9-Dihydroxy-2,10-dimethoxy-7-methyl-6H-naphtho[2,3-h]chromene-6,11,12-trione; 2,10-Dimethoxy-4,9-dihydroxy-7-methyl-6H-naphtho[2,3-h]chromene-6,11,12-trione; Antibiotic Tcm A2; NSC 339775
EINECS	Contact for details

Quality Control

Our Tetracenomycin A2 is produced and handled under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for research applications. Each batch is analyzed using advanced chromatographic and spectroscopic techniques, including HPLC and NMR, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be kept under an inert atmosphere or in a desiccator after opening to prevent degradation. For long-term storage, consider storing at -20°C.

Specification

Item	Specification
Appearance	Yellow to Orange Powder
Identification (HPLC)	Conforms to Reference Standard
Identification (NMR)	Conforms to Structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.