Description

Tetronomycin is a complex polyether ionophore antibiotic isolated from *Streptomyces* species. This compound is valued for its potent biological activity, particularly as a highly effective ionophore for divalent cations, which disrupts cellular ion gradients. It serves as a critical research tool in biochemistry and microbiology for studying ion transport mechanisms and membrane function. Key industrial and research applications include its use as a reference standard and in exploratory studies for novel antimicrobial agents.

Application

• Biochemical Research: As a potent ionophore for divalent cations (e.g., Mg²⁺, Ca²⁺) to study transmembrane ion transport, membrane permeability, and cellular signaling pathways.
• Microbiological Studies: Used as a reference antibiotic in research to investigate mechanisms of action against Gram-positive bacteria and other susceptible microorganisms.
• Pharmaceutical R&D: Serves as a lead compound or biological tool in the discovery and development of new antimicrobial and antiparasitic agents.
• Veterinary Research: Investigated for potential applications in animal health due to its ionophoric and antimicrobial properties.
• Academic Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and comparative studies in university and institutional labs.
• Cell Biology: Utilized to manipulate intracellular cation concentrations, facilitating studies on enzyme regulation, apoptosis, and other cation-dependent cellular processes.

Basic Information

Product Name	Tetronomycin
CAS No.	82206-10-8
Molecular Formula	C₄₀H₆₈O₁₂
Molecular Weight	740.96 g/mol
Synonyms	Tetronomycin; Antibiotic M188; M 188; Antibiotic M-188; Tetronomycin A; (2R,4S,5R,6R,7S,9S,11S,12R,13S,14S,16R,18R,20S,22S,23R,24S,25R,26S,27R,28R)-5,6,11,13,14,16,18,20,22,23,24,25,26,27,28-Pentadecahydroxy-2,4,7,9,12,15,15,19,19-nonamethyl-3,21-dioxapentacyclo[19.5.1.1⁴,⁷.0²,⁹.0¹³,²⁷]octacos-29-ene-8,17-dione
EINECS	Contact for details

Quality Control

Our Tetronomycin is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, spectroscopic identification (IR, NMR), and microbiological assay verification to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with our stringent specifications for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Potency (Microbiological Assay)	≥ 900 µg/mg
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.