Description

1,25-Dihydroxy-23-Oxo-Vitamin D3 is a biologically significant metabolite and synthetic analog of vitamin D, distinguished by its unique 23-oxo modification. This compound is of critical importance for research into the vitamin D endocrine system, particularly in studying receptor binding affinity and metabolic pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and manufacturers of high-purity reference standards for metabolic studies, drug discovery, and analytical method development.

Application

• Pharmaceutical Research & Development: A key intermediate and reference standard in the development of novel vitamin D receptor (VDR) modulators and analogs for therapeutic applications.
• Biochemical Research: Used to study the metabolism, catabolism, and biological activity of vitamin D and its derivatives in cellular and animal models.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for the quantification and identification of vitamin D metabolites in complex matrices via HPLC, LC-MS, or GC-MS.
• Endocrinology Studies: Investigates the role of specific vitamin D metabolites in calcium homeostasis, bone metabolism, and immune system regulation.
• Drug Discovery Pipeline: Employed in high-throughput screening (HTS) assays to identify and characterize new compounds targeting the VDR pathway.

Basic Information

Product Name	1,25-Dihydroxy-23-Oxo-Vitamin D3
CAS No.	82095-23-6
Molecular Formula	C₂₇H₄₂O₅
Molecular Weight	446.62 g/mol
Synonyms	23-Oxo-1,25-dihydroxyvitamin D3; 23-Oxocalcitriol; 1,25-Dihydroxy-23-oxocholecalciferol; 23-Oxo-1α,25-dihydroxyvitamin D₃; (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R)-6-Hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
EINECS	Contact for details

Quality Control

Our 1,25-Dihydroxy-23-Oxo-Vitamin D3 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. For specific purity requirements or custom analytical protocols, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed under an inert atmosphere if specified and allowed to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.