Description

O,Oμ-Bis(2-Azidoethyl)Polyethylene Glycol, Peg-Diazide CAS NO 82055-94-5 is a specialized bifunctional polyethylene glycol derivative featuring reactive azide groups at both termini. This compound matters as a versatile cross-linking agent and click chemistry precursor, enabling efficient, high-yield conjugation and polymer network formation under mild conditions. It is essential for researchers and manufacturers in bioconjugation, hydrogel synthesis, and advanced material science who require reliable, high-purity building blocks for innovative product development.

Application

• Bioconjugation and Protein PEGylation: Used to attach polyethylene glycol (PEG) chains to therapeutic proteins, peptides, or antibodies to enhance solubility, stability, and circulation half-life.
• Hydrogel and Biomaterial Fabrication: Serves as a key cross-linker via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) to create tunable, biocompatible hydrogel networks for drug delivery and tissue engineering.
• Polymer and Dendrimer Synthesis: Acts as a functional initiator or macromonomer in the synthesis of block copolymers, star polymers, and dendrimers with precise architecture.
• Surface Modification and Functionalization: Enables the covalent attachment of PEG layers or specific ligands to surfaces (e.g., nanoparticles, chips, medical devices) to impart stealth properties or bioactivity.
• Diagnostic and Imaging Agent Development: Facilitates the labeling of biomarkers, antibodies, or nanoparticles with imaging probes (e.g., fluorescent dyes, radionuclides) for diagnostic applications.
• Click Chemistry Reagent: A fundamental reagent in click chemistry toolkits for rapid, modular, and high-fidelity synthesis of complex molecules and materials in research and development.

Basic Information

Product Name	O,Oμ-Bis(2-Azidoethyl)Polyethylene Glycol, Peg-Diazide
CAS No.	82055-94-5
Molecular Formula	C2n+4H4n+8N6On+1 (n = PEG repeat units)
Molecular Weight	Variable (dependent on PEG chain length, e.g., 250, 500, 1000, 2000 Da). Contact for details.
Synonyms	PEG-Diazide; α,ω-Bis(2-azidoethyl)poly(ethylene glycol); Poly(ethylene glycol) bis(2-azidoethyl) ether; Azido-PEG-Azido; Bis(2-azidoethyl) PEG; PEG bis(azidoethyl) ether; Diazido-PEG; Azido-Terminated PEG
EINECS	Contact for details

Quality Control

Our Peg-Diazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent functionality, and batch-to-batch reproducibility. Key parameters such as azide content, molecular weight distribution (by GPC), and residual solvents are verified. A comprehensive Certificate of Analysis (COA) documenting identity, purity, and assay is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C for long-term stability. This product is light-sensitive (store away from light) and may be moisture-sensitive. Keep away from heat, sparks, open flames, and strong reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid (grade dependent)
Identification (IR)	Conforms to reference spectrum
Assay (Azide Content)	≥ 95% (by titration or 1H NMR)
PEG Average Mn	As specified (e.g., 250, 500, 1000, 2000 Da ± 5%)
Polydispersity Index (PDI)	≤ 1.05 (by GPC)
Water Content	≤ 0.5% (by KF titration)
Residual Solvents	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.