Description

N6-Methyladenosine 5'-Monophosphate Sodium Salt is a chemically modified nucleotide monophosphate, serving as a critical biochemical tool and reference standard. This compound is essential for research into RNA epigenetics, specifically the study of the m6A modification which regulates gene expression, mRNA stability, and cellular differentiation. It is primarily utilized by researchers and manufacturers in the fields of life science research, pharmaceutical development, and diagnostic assay production.

Application

• Biochemical Research: As a reference standard for the identification and quantification of N6-methyladenosine (m6A) in RNA samples via techniques like LC-MS/MS or HPLC.
• Enzyme Activity Assays: Used as a substrate or inhibitor in studies of methyltransferases (writers), demethylases (erasers), and binding proteins (readers) involved in the m6A pathway.
• Diagnostic Kit Development: Incorporated as a key component in ELISA or other immunoassay kits designed to detect m6A levels for research or clinical diagnostic purposes.
• Pharmaceutical R&D: Employed in high-throughput screening campaigns to discover and validate novel therapeutics targeting the m6A modification machinery for oncology, neurology, and virology.
• Synthesis of Modified Oligonucleotides: Serves as a building block for the solid-phase synthesis of RNA strands containing site-specific m6A modifications for functional studies.
• Cell Culture & Epitranscriptomics: Used in metabolic labeling experiments to trace and understand the dynamics of RNA methylation in living cells.

Basic Information

Item	Detail
Product Name	N6-Methyladenosine 5'-Monophosphate Sodium Salt
CAS No.	81921-35-9
Molecular Formula	C11H14N5O7P • xNa
Molecular Weight	407.22 g/mol (Free acid)
Synonyms	m6A 5'-Monophosphate Sodium Salt; N6-Methyladenosine 5'-Monophosphate; 6-Methyladenosine 5'-Monophosphate; m6AMP Na Salt; N(6)-Methyladenosine 5'-monophosphoric acid sodium salt; 6-Methyladenylic acid sodium salt; Adenosine, N6-methyl-, 5'-(dihydrogen phosphate), sodium salt
EINECS	Contact for details

Quality Control

Our N6-Methyladenosine 5'-Monophosphate Sodium Salt is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry for identity verification, to ensure it meets the high standards required for sensitive research applications. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0 %
Solubility	Clear, colorless solution in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.