Description

Clonidine 4-Isothiocyanate is a key chemical intermediate, specifically a reactive derivative of the pharmaceutical agent clonidine. This compound is primarily valued for its isothiocyanate functional group, which enables covalent conjugation to biomolecules for research and diagnostic applications. It is essential for researchers and manufacturers in the pharmaceutical and life science sectors developing targeted probes, assays, and novel therapeutic conjugates.

Application

• Bioconjugation Reagent: For the covalent labeling of proteins, antibodies, and other biomolecules to create research tools and diagnostic conjugates.
• Affinity Probe Synthesis: Used in the development of molecular probes for studying α-2 adrenergic receptors and related neurological pathways.
• Pharmaceutical Intermediate: Serves as a critical building block in the research and development of novel clonidine-derived therapeutic agents.
• Diagnostic Kit Development: Employed in the manufacturing of components for immunoassays and other in-vitro diagnostic (IVD) tests.
• Chemical Biology Research: A tool for chemoproteomics and activity-based protein profiling (ABPP) to explore protein function.
• Radioligand Precursor: Potential intermediate for synthesizing radiolabeled compounds for positron emission tomography (PET) imaging studies.

Basic Information

Product Name	Clonidine 4-Isothiocyanate
CAS No.	81913-29-3
Molecular Formula	C10H9Cl2N3S
Molecular Weight	274.17 g/mol
Synonyms	4-Isothiocyanatoclonidine; 2-[(2,6-Dichlorophenyl)imino]imidazolidine-4-isothiocyanate; Clonidine Isothiocyanate; Clonidine-4-ITC; NCS-Clonidine; 4-ITC-Clonidine; (2,6-Dichlorophenyl)iminoimidazolidinyl-4-isothiocyanate
EINECS	Contact for details

Quality Control

Our Clonidine 4-Isothiocyanate is produced under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in common organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.