Description

2'-Deoxy-3-Methylpseudouridine is a high-purity, chemically modified nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound is valued for its role in enhancing the stability and efficacy of therapeutic nucleic acids, particularly in mRNA-based applications. It is a critical raw material for researchers and manufacturers in the biopharmaceutical industry focused on next-generation vaccines, gene therapies, and other oligonucleotide therapeutics.

Application

• mRNA Vaccine & Therapeutic Manufacturing: A key modified nucleoside used to incorporate into mRNA sequences to reduce immunogenicity and increase translational efficiency.
• Oligonucleotide Synthesis: Serves as a phosphoramidite building block for the solid-phase synthesis of modified antisense oligonucleotides (ASOs) and siRNA.
• Biochemical Research: Used as a reference standard and reagent in studies investigating RNA structure, function, and metabolism.
• Drug Discovery Platforms: Employed in high-throughput screening and the development of novel nucleic acid-based drug candidates.
• Diagnostic Probe Development: Utilized in the design of specialized probes and primers for sensitive molecular diagnostics.

Basic Information

Product Name	2'-Deoxy-3-Methylpseudouridine
CAS No.	81691-10-3
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	3-Methyl-2'-deoxypseudouridine; 3-Methyl-d-ψ; 3-Methyl-2'-deoxy-5-ribosyluracil; 1-(2-Deoxy-β-D-ribofuranosyl)-3-methyl-2,4(1H,3H)-pyrimidinedione; 3-Methyl-2'-deoxy-ψ-uridine; d-3mψ; 2'-Deoxy-3-methyl-ψ-uridine
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-3-Methylpseudouridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with detailed chromatographic data and are committed to supporting customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.