Description

1H-Pyrrolizine-2-Carbonyl Chloride, 1-Oxo- (9Ci) is a specialized heterocyclic building block and reactive intermediate of significant interest in advanced organic synthesis. Its core value lies in its ability to introduce the 1-oxo-pyrrolizine-2-carbonyl moiety, a key structural motif for developing novel pharmacologically active compounds. This high-purity reagent is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecules in medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities within the pyrrolizine chemical space.
• Agrochemical Development: Serves as a precursor in the creation of new active ingredients for crop protection products, such as herbicides and insecticides.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A key starting material for fine chemical manufacturers offering bespoke synthesis services to the life sciences sector.
• Academic Research: Utilized in university and institutional laboratories for methodological development and exploring new heterocyclic chemistry.

Basic Information

Product Name	1H-Pyrrolizine-2-Carbonyl Chloride, 1-Oxo- (9Ci)
CAS No.	81400-08-0
Molecular Formula	C8H6ClNO2
Molecular Weight	183.59 g/mol
Synonyms	1-Oxo-1H-pyrrolizine-2-carbonyl chloride; 1-Oxo-2-pyrrolizinecarbonyl chloride; 2-Carboxy-1-oxo-1H-pyrrolizine chloride; 1H-Pyrrolizine-2-carbonyl chloride, 1-oxo-; 1-Oxopyrrolizine-2-carbonyl chloride; Pyrrolizine-2-carbonyl chloride, 1-oxo-; 2-(Chlorocarbonyl)-1-oxo-1H-pyrrolizine
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolizine-2-Carbonyl Chloride, 1-Oxo- (9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.