Description

5'-Adenylic Acid, Monoanhydride With (Dichlorophosphonomethyl)Phosphonic Acid is a specialized nucleotide derivative with a unique bisphosphonate structure, serving as a critical high-energy phosphate donor and enzyme cofactor analog. This compound is valued for its ability to act as a potent inhibitor or substrate analog in biochemical pathways, particularly those involving ATP-dependent enzymes. It is essential for researchers and manufacturers in pharmaceutical development, enzymology studies, and the synthesis of nucleotide-based prodrugs or active pharmaceutical ingredients (APIs).

Application

• Biochemical Research: Used as a substrate analog or inhibitor in enzymatic assays to study kinase, ATPase, and other ATP-dependent enzyme mechanisms.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of novel nucleotide-based therapeutics, including antiviral and anticancer prodrugs.
• Enzyme Co-factor Studies: Employed to investigate the role of ATP and its analogs in cellular energy transfer and signal transduction pathways.
• Metabolic Pathway Analysis: Utilized as a tool compound to probe and modulate specific steps in nucleotide metabolism within in vitro systems.
• Diagnostic Reagent Development: Acts as a component in the formulation of diagnostic kits for measuring enzymatic activity in clinical or research settings.
• Precursor for Labeled Compounds: Can be used as a starting material for synthesizing radiolabeled or fluorescently tagged nucleotide analogs for tracer studies.

Basic Information

Item	Detail
Product Name	5'-Adenylic Acid, Monoanhydride With (Dichlorophosphonomethyl)Phosphonic Acid
CAS No.	81336-74-5
Molecular Formula	C11H15Cl2N5O12P3
Molecular Weight	598.09 g/mol
Synonyms	Adenosine 5'-(tetrahydrogen triphosphate); 5'-Adenylic Acid, Monoanhydride with (Dichlorophosphonomethyl)phosphonic Acid; Adenosine-5'-[beta,γ-dichloromethylene] triphosphate; beta,γ-Dichloromethylene-ATP; beta,γ-Dichloromethyleneadenosine 5'-triphosphate; Dichloromethylene-ATP; DcM-ATP; ATP analog, bisphosphonate
EINECS	Contact for details

Quality Control

Our production of this high-purity biochemical adheres to stringent quality protocols. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and structural integrity. We provide comprehensive Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data, ensuring traceability and compliance with research-grade specifications. Stability and impurity profiles are routinely monitored to guarantee batch-to-batch consistency for critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This compound is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation or storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.