Description

1H-Pyrazole-4-Carbonyl Chloride, 5-Cyano-1-Methyl- (9Ci) is a versatile and highly reactive chemical intermediate, specifically a functionalized pyrazole derivative. Its core value proposition lies in its role as a key building block for synthesizing more complex heterocyclic compounds, enabling the introduction of both cyano and acid chloride functionalities in a single step. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it is used to develop novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the pyrazole core's bioactivity.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic materials, including polymers and liquid crystals with specific electronic properties.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1H-Pyrazole-4-Carbonyl Chloride, 5-Cyano-1-Methyl- (9Ci)
CAS No.	81303-60-8
Molecular Formula	C6H4ClN3O
Molecular Weight	169.57 g/mol
Synonyms	5-Cyano-1-methyl-1H-pyrazole-4-carbonyl chloride; 1-Methyl-5-cyano-1H-pyrazole-4-carbonyl chloride; 5-Cyano-1-methylpyrazole-4-carbonyl chloride; 4-Pyrazolecarbonyl chloride, 5-cyano-1-methyl-; 1-Methyl-1H-pyrazole-4-carbonyl chloride, 5-cyano-; 81303-60-8; 5-Cyano-1-methyl-1H-pyrazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Our 1H-Pyrazole-4-Carbonyl Chloride, 5-Cyano-1-Methyl- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to handle and store the material under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.