Description

1H-Pyrazole-4-Carbonyl Chloride, 3-Cyano-1-Methyl- (9Ci) is a high-value heterocyclic building block and key synthetic intermediate. Its core value lies in its highly reactive acid chloride group and functionalized pyrazole ring, enabling efficient derivatization for complex molecule synthesis. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing functionalized pyrazole cores.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the development of novel organic frameworks and functional polymers.
• Custom Synthesis & Contract Manufacturing: A key reagent for custom chemical synthesis services targeting complex, multi-step organic molecules.
• Bioconjugation Chemistry: The reactive carbonyl chloride group allows for coupling reactions in probe and linker molecule development.

Basic Information

Product Name	1H-Pyrazole-4-Carbonyl Chloride, 3-Cyano-1-Methyl- (9Ci)
CAS No.	81303-58-4
Molecular Formula	C6H4ClN3O
Molecular Weight	169.57 g/mol
Synonyms	3-Cyano-1-methyl-1H-pyrazole-4-carbonyl chloride; 1-Methyl-3-cyano-1H-pyrazole-4-carbonyl chloride; 1-Methyl-1H-pyrazole-4-carbonyl chloride, 3-cyano-; 3-Cyano-1-methylpyrazole-4-carbonyl chloride; 4-Carbonyl chloride-3-cyano-1-methylpyrazole; 1-Methyl-3-cyanopyrazole-4-carboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 1H-Pyrazole-4-Carbonyl Chloride, 3-Cyano-1-Methyl- (9Ci) is produced and tested under strict quality management protocols to ensure consistency and purity for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.