Description

5'-Dmt-Ribo Adenosine (n-Bz) is a high-purity, protected nucleoside derivative, specifically designed for advanced oligonucleotide synthesis. This compound is a critical building block for the solid-phase synthesis of RNA and modified oligonucleotides, offering precise control over the final product's sequence and functionality. It is an essential raw material for pharmaceutical R&D, biotechnology companies, and diagnostic manufacturers engaged in developing therapeutic nucleic acids, antisense oligonucleotides, and complex molecular probes.

Application

• Oligonucleotide Synthesis: A key phosphoramidite precursor for the automated solid-phase synthesis of RNA strands.
• Therapeutic RNA Development: Used in the research and production of siRNA, miRNA, and mRNA for therapeutic applications.
• Antisense Technology: Serves as a monomer in the creation of antisense oligonucleotides (ASOs) for gene silencing.
• Diagnostic Probe Manufacturing: Essential for producing labeled probes and primers used in PCR, sequencing, and molecular diagnostics.
• Biochemical Research: Employed in academic and industrial labs for studying nucleic acid structure, function, and interactions.
• API Intermediate: Acts as a sophisticated intermediate in the synthesis of active pharmaceutical ingredients (APIs) based on nucleic acids.

Basic Information

Product Name	5'-Dmt-Ribo Adenosine (n-Bz)
CAS No.	81246-82-4
Molecular Formula	C38H39N5O8
Molecular Weight	693.75 g/mol
Synonyms	5'-O-(4,4'-Dimethoxytrityl)-N6-benzoyladenosine; N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)adenosine; 5'-DMT-N6-Bz-Adenosine; N6-Bz-5'-DMT-A; DMT-rA(Bz); Adenosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-N-benzoyl-; Protected Adenosine Derivative
EINECS	Contact for details

Quality Control

Every batch of 5'-Dmt-Ribo Adenosine (n-Bz) is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the stringent requirements of oligonucleotide synthesis. Our products are characterized by HPLC, NMR, and mass spectrometry to guarantee identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with in-house specifications tailored for pharmaceutical and diagnostic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions or a dry inert atmosphere to maintain stability and prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.