Description

Cyclobutyl Chloroformate is a versatile and reactive chloroformate ester, a key building block in organic synthesis. Its primary value lies in its role as a reagent for the introduction of the cyclobutyloxycarbonyl (Cbc) protecting group, particularly for amines in peptide synthesis and pharmaceutical intermediate manufacturing. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A critical reagent for the preparation of active pharmaceutical ingredients (APIs) and prodrugs, especially in carbamate and urea formation.
• Peptide Chemistry: Used to introduce the cyclobutyloxycarbonyl (Cbc) protecting group for amino acids, offering an alternative to Boc and Fmoc groups with different deprotection kinetics.
• Agrochemical Manufacturing: Serves as a building block for synthesizing herbicides, fungicides, and insecticides that incorporate the cyclobutyl moiety.
• Polymer Science: Employed in the synthesis of specialty polymers and functional materials, such as polycarbonates and polyurethanes with tailored properties.
• Cross-coupling Reactions: Acts as an electrophile in palladium-catalyzed and other metal-mediated coupling reactions to form carbon-heteroatom bonds.
• Chemical Research & Development: A valuable tool for medicinal chemistry and process chemistry for exploring new synthetic routes and novel compound libraries.

Basic Information

Product Name	Cyclobutyl Chloroformate
CAS No.	81228-87-7
Molecular Formula	C5H7ClO2
Molecular Weight	134.56 g/mol
Synonyms	Cyclobutyl carbonochloridate; Chloroformic acid cyclobutyl ester; Cyclobutyloxycarbonyl chloride; Cbc-Cl; Cyclobutyl chlorocarbonate; Carbonochloridic acid, cyclobutyl ester; Cyclobutyl chloroformate
EINECS	Contact for details

Quality Control

Our Cyclobutyl Chloroformate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C. Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Density (at 20°C)	~1.18 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.