Description

2''-Formimidoylistamycin A is a chemically modified derivative of the lincosamide antibiotic lincomycin, characterized by the introduction of a formimidoyl group. This structural modification is of significant interest in pharmaceutical research for exploring new antibacterial agents with potentially enhanced activity or altered pharmacokinetic profiles. It serves as a critical intermediate and reference standard for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on antibiotic development and microbial resistance studies.

Application

• Pharmaceutical Research Intermediate: Serves as a key synthetic precursor in the development of novel lincosamide antibiotic analogs.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of related antibiotic substances.
• Microbiological Studies: Employed in research to study structure-activity relationships (SAR) and mechanisms of action against resistant bacterial strains.
• Process Chemistry: Utilized in scale-up and optimization studies for the manufacturing of advanced antibiotic compounds.
• Academic Research: A valuable tool for universities and research institutes investigating new pathways for combating bacterial infections.

Basic Information

Product Name	2''-Formimidoylistamycin A
CAS No.	81202-83-7
Molecular Formula	C19H35N3O6S
Molecular Weight	433.57 g/mol
Synonyms	2''-Formimidoyllincomycin; N-[(2S,4R)-1-Methyl-4-propyl-2-pyrrolidinyl]carbonyl]-6,8-dideoxy-6-[[(1S,2S,3R,4S,6R)-4,6-dihydroxy-2,3,4-trimethylcyclohexyl]amino]-1-thio-D-erythro-α-D-galacto-octopyranoside 2''-(N-formimidoyl); Formimidoyllincomycin derivative; Lincomycin formimidoyl derivative; Antibiotic U-24729A (derivative)
EINECS	Contact for details

Quality Control

Our 2''-Formimidoylistamycin A is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) with detailed chromatographic data are provided to ensure traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the certificate of analysis. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions when opening.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Assay	≥ 97.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.