Description

5'-Amino-5'-Deoxyadenosine p-Toluenesulfonate Salt is a chemically modified nucleoside derivative, serving as a crucial building block and intermediate in advanced biochemical research and pharmaceutical development. This compound is valued for its role in the synthesis of oligonucleotide analogs and as a substrate for studying enzyme mechanisms, particularly those involving adenosine deaminases and kinases. It is primarily utilized by researchers and manufacturers in the fields of nucleic acid chemistry, medicinal chemistry, and biotechnology for developing novel therapeutics and diagnostic probes.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Substrate for enzymatic studies, particularly for adenosine deaminase and kinase activity assays.
• Oligonucleotide Synthesis: Modified building block for creating antisense oligonucleotides and siRNA with enhanced stability or targeting properties.
• Medicinal Chemistry: Core scaffold for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Diagnostic Development: Used in the creation of labeled probes for molecular diagnostics and imaging.
• Enzyme Inhibitor Design: Serves as a lead compound for developing inhibitors of purine metabolism enzymes.

Basic Information

Product Name	5'-Amino-5'-Deoxyadenosine p-Toluenesulfonate Salt
CAS No.	81090-75-7
Molecular Formula	C17H22N6O5S
Molecular Weight	422.46 g/mol
Synonyms	5'-Amino-5'-deoxyadenosine tosylate salt; 5'-Amino-5'-deoxyadenosine p-toluenesulfonate; 9-[(2R,3S,4R,5R)-5-Amino-3,4-dihydroxyoxolan-2-yl]-6-aminopurin-1-ium; 4-methylbenzenesulfonate; 5'-NH2-5'-dA Tosylate; Adenosine, 5'-amino-5'-deoxy-, 4-methylbenzenesulfonate (1:1); 5'-Amino-5'-deoxyadenosine monotosylate
EINECS	Contact for details

Quality Control

Our 5'-Amino-5'-Deoxyadenosine p-Toluenesulfonate Salt is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.